王亚军 博士、教授、博士生导师
联系方式：办公室电话：028-85415025
电子邮件：[email protected] 或[email protected]
一、 学习与工作简历
1987-1991: 西南大学 明升国际 理学学士
1991-1994: 浙江大学 生物系 硕士
1994-1999: 浙江大学 生物系 助教、讲师
1999-2003: 香港中文大学(The Chinese University of Hong Kong) 博士
2003-2004: 香港中文大学 博士后
2004-2007: 香港大学 (The University of Hong Kong) 博士后
2007-2009: 香港大学 研究助理教授
2009-现在： 浙江大学 明升国际 教授
二、研究简介
王亚军教授任职于明升m88备用网站，细胞生物学方向博士生导师。王亚军教授博士期间(1999-2003)致力于动物卵泡发育机制解析，以斑马鱼为模型，探究EGF、Activin等对卵泡发育的调节。完成博士学位攻读后，王亚军教授入职香港大学生物科学院，以家鸡为模型，致力于基因功能鉴定，探究动物生长、繁殖与代谢调控机理。
2009年，王亚军教授全职回到浙江大学，在“浙江大学引进人才基金”支持下，组建动物功能基因组学研究平台，主以家鸡（或斑马鱼）等为模型，探究：1) 受体功能与信号传导；2) 下丘脑神经元对垂体功能的调节；3) 垂体激素对动物生长，繁殖与代谢的影响；4) 肠道微生物对动物免疫与代谢等过程的调节；5) 动物基因编辑与转基因技术。
三、研究方向
动物细胞生物学、 信号传导、 内分泌与代谢、分子遗传学
四、学术兼职：
1) 担任SCI杂志《Frontiers in Physiology》(IF=4.566) - Avian Physiology方向副主编(Associate Editor)
2) 担任SCI杂志《Frontiers in Endocrinology》(IF=5.555) - 评审编辑(Reviewer Editor)。
代表性论文：
1. Liu, M.#, Bu, G.#, Wan, Y., Zhang, J., Mo, C., Li, J., & Wang, Y.* (2022). Evidence for Neuropeptide W Acting as a Physiological Corticotropin-releasing Inhibitory Factor in Male Chickens. Endocrinology, 163, 7. (*通讯) (IF = 4.736)
2. Zhang J.#, Lv C.#, Mo C., Liu M., Wan Y., Li J.* & Wang Y.* (2021) Single-Cell RNA Sequencing Analysis of Chicken Anterior Pituitary: A Bird’s-Eye View on Vertebrate Pituitary. Frontiers in Physiology 12, 1-21. (*通讯) (IF = 4.566)
3. Luo J.#, Lu C.#, Feng M., Dai L., Wang M., Qiu Y., Zheng H., Liu Y., Li L., Tang B., Xu C., Wang Y.* & Yang X.* (2021) Cooperation between liver-specific mutations of pten and tp53 genetically induces hepatocarcinogenesis in zebrafish. Journal of Experimental and Clinical Cancer Research 40, 1-17. (*通讯) (IF = 11.16)
4. Li Z., Jiang B., Cao B., Zhang Z., Zhang J., Li J., Huang Y.* & Wang Y.* (2021) Characterization of four orphan receptors (Gpr3, gpr6, gpr12 and gpr12l) in chickens and ducks and regulation of gpr12 expression in ovarian granulosa cells by progesterone. Genes 12. (*通讯) (IF = 4.096)
5. Fang C.#, Zhang J.#, Wan Y., Li Z., Qi F., Dang Y., Li J. & Wang Y.* (2021) Neuropeptide S (NPS) and its receptor (NPSR1) in chickens: cloning, tissue expression, and functional analysis. Poultry Science 100, 101445. (*通讯) (IF = 3.352)
6. Cui L.#, Lv C.#, Zhang J., Li J.* & Wang Y.* (2021) Characterization of four urotensin II receptors (UTS2Rs) in chickens. Peptides 138, 170482. (*通讯) (IF = 3.75)
7. Zhang J.#, Li J.#, Wu C., Hu Z., An L., Wan Y., Fang C., Zhang X., Li J.* & Wang Y.* (2020) The Asp298Asn polymorphism of melanocortin-4 receptor (MC4R) in pigs: evidence for its potential effects on MC4R constitutive activity and cell surface expression. Anim Genet 51, 694-706. (*通讯) (IF = 2.841)
8. Liu T., Deng Y., Zhang Z., Cao B., Li J., Sun C., Hu Z., Zhang J.*, Li J. & Wang Y.* (2020) Melanocortin receptor 4 (MC4R) signaling system in nile tilapia. International Journal of Molecular Sciences 21, 1-19. (*通讯) (IF = 4.556)
9. Bu G., Cui L., Lv C., Lin D., Huang L., Li Z., Li J., Zeng X.* & Wang Y.* (2020) Opioid Peptides and Their Receptors in Chickens: Structure, Functionality, and Tissue Distribution. Peptides 128, 170307. (*通讯) (IF = 2.843)
10. Li X#., Li Z#., Deng Y., Zhang J., Li J. & Wang Y.* (2020) Characterization of a novel thyrotropin-releasing hormone receptor, TRHR3, in chickens. Poultry Science 99, 1643-54. (*通讯) (IF = 2.659)
11. Chen J#., Huang S#., Zhang J., Li J. & Wang Y.* (2020) Characterization of the Neuropeptide FF (NPFF) Gene in Chickens: Evidence for a Single Bioactive NPAF Peptide Encoded by the NPFF Gene in Birds. Domestic Animal Endocrinology, 106435. (*通讯) (IF = 1.778)
12. Wu C., Lv C., Wan Y.P., Li X.X., Zhang J.N.*, Li J. & Wang Y.*(2019) Arginine vasotocin (AVT)/mesotocin (MT) receptors in chickens: Evidence for the possible involvement of AVT-AVPR1 signaling in the regulation of oviposition and pituitary prolactin expression. General and comparative endocrinology 281, 91-104. (*通讯) (IF = 2.445)
13. Mo C., Lv C., Huang L., Li Z., Zhang J., Li J. & Wang Y.* (2019) Regulation of Pituitary Cocaine- and Amphetamine-Regulated Transcript Expression and Secretion by Hypothalamic Gonadotropin-Releasing Hormone in Chickens. Front Physiol 10, 882. (*通讯) (IF = 3.201)
14. Liu H.K., Luo Q., Zhang J.N., Mo C.H., Wang Y.*& Li J. (2019) Endothelins (EDN1, EDN2, EDN3) and their receptors (EDNRA, EDNRB, EDNRB2) in chickens: Functional analysis and tissue distribution. General and comparative endocrinology 283, 113231. (*通讯) (IF = 2.445)
15. Bu G#., Fan J#., Yang M., Lv C., Lin Y., Li J., Meng F., Du X., Zeng X., Zhang J., Li J. & Wang Y.* (2019) Identification of a Novel Functional Corticotropin-Releasing Hormone (CRH2) in Chickens and Its Roles in Stimulating Pituitary TSHbeta Expression and ACTH Secretion. Frontiers in endocrinology 10, 595. (*通讯) (IF = 3.634)
16. Zhang J#, Zhou Y, Wu C, Wan Y, Fang C, Li J, Fang W, Yi R, Zhu G, Li J*, Wang Y* (2018) Characterization of the Apelin/Elabela Receptors (APLNR) in Chickens, Turtles, and Zebrafish: Identification of a Novel Apelin-Specific Receptor in Teleosts. Frontiers in endocrinology, 9:756. (*通讯) (IF = 3.519)
17. Zhang J#, Wan Y#, Fang C, Chen J, Ouyang W, Li J*, Wang Y* (2018) The orphan G protein-coupled receptor 25 (GPR25) is activated by Apelin and Apela in non-mammalian vertebrates. Biochemical and biophysical research communications, 501(2):408-414. (*通讯) (IF = 2.559)
18. Wan Y#, Zhang J#, Fang C, Chen J, Li J, Li J*, Wu C, Wang Y* (2018) Characterization of neuromedin U (NMU), neuromedin S (NMS) and their receptors (NMUR1, NMUR2) in chickens. Peptides, 101:69-81. (*通讯) (IF = 2.851)
19. Lv C#, Mo C, Liu H, Wu C, Li Z, Li J*, Wang Y* (2018) Dopamine D2-like receptors (DRD2 and DRD4) in chickens: Tissue distribution, functional analysis, and their involvement in dopamine inhibition of pituitary prolactin expression. Gene, 651:33-43. (*通讯) (IF = 2.498)
20. Zhang J#, Li X, Zhou Y, Cui L, Li J, Wu C, Wan Y, Li J*, Wang Y* (2017) The interaction of MC3R and MC4R with MRAP2, ACTH, alpha-MSH and AgRP in chickens. The Journal of endocrinology, 234(2):155-174. (*通讯) (IF = 4.706)
21. Mo C#, Huang L, Cui L, Lv C, Lin D, Song L, Zhu G, Li J*, Wang Y* (2017) Characterization of NMB, GRP and their receptors (BRS3, NMBR and GRPR) in chickens. J Mol Endocrinol, 59(1):61-79. (*通讯) (IF = 3.577) (杂志封面图片)
22. Cui L#, Lv C, Zhang J, Mo C, Lin D, Li J, Wang Y* (2017) Characterization of melanin-concentrating hormone (MCH) and its receptor in chickens: Tissue expression, functional analysis, and fasting-induced up-regulation of hypothalamic MCH expression. Gene, 615:57-67. (*通讯) (IF = 2.415)
23. Shunyu Gao#, Jiannan Zhang, Chen He, Fengyan Meng, Guixian Bu, Guoqiang Zhu, Juan Li, Yajun Wang* (2017) Molecular characterization of neuropeptide Y (NPY) receptors (Y1, Y4 and Y6) and investigation of the tissue expression of their ligands (NPY, PYY and PP) in chickens. General and Comparative Endocrinology 240, 46–60 (*通讯) (IF = 2.67)
24. Bu G#, Lin D, Cui L, Huang L, Lv C, Huang S, Wan Y, Fang C, Li J, Wang Y*. (2016) Characterization of Neuropeptide B (NPB), Neuropeptide W (NPW), and Their Receptors in Chickens: Evidence for NPW Being a Novel Inhibitor of Pituitary GH and Prolactin Secretion. Endocrinology. 157:3562-76. (*通讯) (IF = 4.159) (获Endocrinology杂志撰文评论)
25. Chen He#, Jiannan Zhang, Shunyu Gao, Fengyan Meng, Guixian Bu, Juan Li, Yajun Wang* (2016), Molecular characterization of three NPY receptors (Y2, Y5 and Y7) in chickens: Gene structure, tissue expression, promoter identification, and functional analysis. General and Comparative Endocrinology 236: 24–34 (*通讯) (IF = 2.67)
26. Cai G#, Mo C#, Huang L, Li Juan*, Wang Y* (2015) Characterization of the Two CART Genes (CART1 and CART2) in Chickens (Gallus gallus). PLoS One 10(5):e0127107. doi: 10.1371 (*通讯) (IF = 2.67)
27. Bu G#, Liang X, Li J, Wang Y* (2015) Extra-pituitary Prolactin (PRL) and Prolactin-like Protein (PRL-L) in Chickens and Zebrafish. General and Comparative Endocrinology. 220:143-153 (IF = 2.67)
28. G. Huang#, C. He, F. Meng, J. Li, J. Zhang, and Y. Wang* (2014) Glucagon-Like Peptide (GCGL) Is a Novel Potential TSH-Releasing Factor (TRF) in Chickens: I) Evidence for Its Potent and Specific Action on Stimulating TSH mRNA Expression and Secretion. Endocrinology, 155: 4568-4580 (*通讯) (IF = 4.644).
29. G Huang#, J Li, H Wang, X Lan, and Y. Wang* (2014) Discovery of a Novel Functional Leptin Protein (LEP) in Zebra Finches: Evidence for the Existence of an Authentic Avian Leptin Gene Predominantly Expressed in the Brain and Pituitary. Endocrinology 155: 3385-96 (*通讯) (IF = 4.644) (* Endocrinology 2014年9月封面论文，并获杂志撰文评述)。
30. Meng F#, Huang G, Gao S, Li J, Yan Z, Wang Y* (2014). Identification of the receptors for somatostatin (SST) and cortistatin (CST) in chickens and investigation of the roles of cSST28, cSST14, and cCST14 in inhibiting cGHRH1–27NH2-induced growth hormone secretion in cultured chicken pituitary cells. Molecular and Cellular Endocrinology 384: 83-95. (*通讯) (IF= 4.241)
31. Mo C#, Zhong Y, Wang Y*, Yan Z, Li J* (2014) Characterization of glucagon-like peptide 2 receptor (GLP2R) gene in chickens: functional analysis, tissue distribution, and developmental expression profile of GLP2R in embryonic intestine. Domestic Animal Endocrinology 48：1-6 (IF = 1.781) (*通讯)
32. Zhang J. #, Cheng S, Wang Y*, Yu X, Li J*. (2014) Identification and characterization of the free fatty acid receptor 2 (FFA2) and a novel functional FFA2-like receptor (FFA2L) for short-chain fatty acids in pigs: Evidence for the existence of a duplicated FFA2 gene (FFA2L) in some mammalian species. Domestic Animal Endocrinology 47:108-118 (*通讯) (IF =1.781).
33. He X#, Meng F, Wang Y, Li J*. (2014) Molecular Cloning and Characterization of Two Pig Vasoactive Intestinal Polypeptide Receptors (VPAC1-R and VPAC2-R). DNA Cell Biol. 33：259-270 (IF=1.991).
34. Bu G#, Wang CY, Cai G, Leung FC*, Xu M, Wang H, Huang G, Li J, Wang Y* (2013) Molecular Characterization of Prolactin Receptor (cPRLR) Gene in Chickens: Gene Structure, Tissue Expression, Promoter Analysis, and Its Interaction with Chicken Prolactin (cPRL) and Prolactin-like Protein (cPRL-L). Molecular and Cellular Endocrinology 370: 149-62.（*通讯）(IF = 4.241).
35. Bu G#, Huang G, Fu H, Li J, Huang S. Wang Y* （2013） Characterization of the novel duplicated PRLR gene at the late-feathering K locus in Lohmann chickens. Journal of Molecular Endocrinology 51, 261–276 （*通讯）(IF = 3.621).
36. Song X#, Wang Y*, Tang Y* (2013) Rapid Diversification of FoxP2 in Teleosts through Gene Duplication in the Teleost-Specific Whole Genome Duplication Event. PLoS One，8(12):e83858.（*通讯）(IF = 3.534).
37. Wang Y*#, Meng F, Zhong Y, Huang G, Li J (2012) Discovery of a Novel Glucagon-like Peptide (GCGL) and its Receptor (GCGLR) in Chickens: Evidence for the Existence of GCGL and GCGLR Genes in Non-mammalian Vertebrates. Endocrinology 153, 5247-5260 (*通讯) (IF = 4.717)
38. Wang Y*#, Wang CY, Wu Y, Huang G, Li J, Leung FC* (2012). Identification of the Receptors for Prolactin-releasing Peptide (PrRP) and Carassius RFamide Peptide (C-RFa) in Chickens. Endocrinology 153: 1861-1874 (*通讯) (IF = 4.717).
39. Wang Y*#, Huang G, Li J., Meng F, He X. Leung F.C* (2012) Characterization of Chicken Secretin (SCT) and Secretin Receptor (SCTR) Genes: A Novel Secretin-like Peptide (SCT-LP) and Secretin Encoded in a Single Gene. Molecular and Cellular Endocrinology 348: 270-280 (*通讯) (IF=4.192).
40. Ho JCW#, Jacobs T, Wang Y*, Leung FC* (2012) Identification and characterization of the chicken galanin receptor GalR2 and a novel GalR2-like receptor (GalR2-L). General and comparative endocrinology, 179: 305-312 (*通讯) (IF=2.823).
41. Kwok AHY#, Wang Y*, Leung FC* (2012) Molecular characterization of prostaglandin F receptor (FP) and E receptor subtype 3 (EP3) in chickens. General and comparative Endocrinology. 179: 88-98 (*通讯) (IF=2.823).
42. Kwok AHY#, Wang Y*, Leung FC* (2012) Molecular characterization of prostaglandin F receptor (FP) and E receptor subtype 1 (EP1) in zebrafish. General and comparative Endocrinology. 178: 216-226 (*通讯) (IF=2.823).
43. Huang G#, Li J, Fu H, Yan Z, Bu G, He X, Wang Y* (2012) Characterization of glucagon-like peptide 1 receptor (GLP1R) gene in chickens: functional analysis, tissue distribution, and identification of its transcript variants. Domestic Animal Endocrinology 43: 1-15 (*通讯). (IF=2.377)
44. Li J#*, Meng F, Song C, Wang Y, Leung FC* (2012) Characterization of chicken visfatin gene: cDNA cloning, Tissue expression, and promoter analysis. Poultry Science, 91: 2885-94 (IF=1.728)
45. Ho JC#, Kwok AH, Zhao D, Wang Y*, Leung FC*. (2011) Characterization of the chicken galanin type I receptor (GalR1) and a novel GalR1-like receptor (GalR1-L). General and Comparative Endocrinology 170: 391-400, (*通讯) (IF=3.267)
46. Ruiqiang Li#, Wei Fan, Geng Tian, Hongmei Zhu, Lin He, ……, Yajun Wang… Lars Bolund, Karsten Kristiansen, Gane Ka-Shu Wong, Maynard Olson, Xiuqing Zhang, Songgang Li, Huanming Yang, Jian Wang & Jun Wang. The sequence and de novo assembly of the giant panda genome. Nature 463: 311-317, 2010 (IF=36.101)
47. Wang Y*#, Li J, Kwok AHY, Ge W, Leung FC* (2010) A novel prolactin-like protein (PRL-L) gene in chickens and zebrafish: Cloning and Characterization of its tissue expression. General and Comparative Endocrinology 166: 200-210 (IF=3.108)
48. Wang Y*#, Li J, Wang CY, Kwok AHY, Leung FC* (2010) Characterization of the receptors for chicken GHRH and GHRH-related peptides: Identification of a novel receptor for GHRH and the receptor for GHRH-LP (PRP). Domestic Animal Endocrinology 38: 13-31 (IF=2.056)
49. Lynch VJ#，Tanzer A, Wang Y, Leung FC, Gellersen B, Emera D, Wagner GP* (2008), Adaptive changes in the transcription factor HoxA-11 are essential for the evolution of pregnancy in mammals. Proc. Natl. Acad. Sci. U S A. 105:14925-14933, (IF=9.598)
50. Wang J#, Wang Y, Li X, Li Juan, Leung FC* (2008) Cloning, tissues distribution and functional characterization of chicken glucagon receptor. Poultry science 87: 2678-2688, (IF=1.603)
51. Kwok AHY#, Wang Y, Wang CY, Leung FC*. (2008), Molecular cloning and characterization of chicken prostaglandin E receptor subtypes 2 and 4 (EP2 and EP4). General and Comparative Endocrinology, 157: 99-106 (IF=2.823)
52. Wang Y#, Li J, Wang CY, Kwok AHY, Leung FC*(2007) Identification of the endogenous ligands for chicken growth hormone-releasing hormone (GHRH) receptor. Evidence for a separate gene encoding GHRH in submammalian vertebrates. Endocrinology 148: 2405-2416 (IF=5.045)
53. Wang Y#, Li J，Wang CY, Kwok AHY, Leung FC* (2007) Epidermal growth factor receptor (EGFR) ligand in the chicken ovary: I) Evidence for heparin binding epidermal growth factor-like growth factor (HB-EGF) as a potential oocyte-derived factor to control granulosa cell proliferation and HB-EGF and Kit ligand expression. Endocrinology 148: 3426 – 3440. (IF=5.045)
54. Wang Y#, Wang Z, Li J, Wang Y, Leung FC* (2007) A database for chicken full-length cDNAs. Physiological Genomics 28:141-5, (IF=3.498)
55. Kwok AHY#, Wang Y, Wang CY, Leung FC. (2007), Cloning of chicken glucocorticoid receptor (GR) and characterization of its expression in pituitary and extra-pituitary tissues. Poultry Science 86: 423-430 (IF=1.603)
56. Wang CY#, Wang Y#, Kwok AHY, Leung FC (2007). Identification of two novel chicken GHRH receptor splice variants: implications for the roles of aspartate 56 in the receptor activation and direct ligand receptor interaction. Journal of Endocrinology 195: 525-536, (IF=2.636)
57. Wang CY#, Wang Y, Li J, Leung FC (2006) Expression profiles of chicken growth hormone-releasing hormone (GHRH) and growth hormone-releasing hormone receptor (GHRHR) during chicken embryonic pituitary development. Poultry Science, 85: 569-576, (IF=1.603)
58. Kwok HF#, So WK, Wang Y, Ge W (2005) Zebrafish gonadotropins and their receptors: I. Cloning and characterization of zebrafish follicle-stimulating hormone and luteinizing hormone receptors: Evidence for their distinct functions in follicle development. Biology of Reproduction, 72: 1370-1381, (IF=3.670)
59. Wang Y# & Ge W (2004) Cloning of Epidermal growth factor (EGF) and EGF receptor from the zebrafish ovary: evidence for EGF as a potential paracrine factor from the oocyte to regulate activin/follistatin system in the follicle cells. Biology of Reproduction, 71: 749-760 (IF=3.670).
60. Wang Y# & Ge W (2004). Developmental profiles of activin βA, βB, and follistatin expression in the zebrafish ovary: evidence for their differential roles during sexual maturation and ovulatory cycle. Biology of Reproduction, 71: 2056-2064, (IF=3.670).
61. Wang Y# & Ge W (2004). Cloning of zebrafish ovarian P450c17 (CYP17, 17α-hydroxylase/ 17,20- lyase) and characterization of its expression in gonadal and extra-gonadal tissues. General and Comparative Endocrinology, 135: 241-249 (IF=3.108)
62. Wang Y# & Ge W (2003) Involvement of cyclic adenosine 3’,5’-monophosphate in the differential regulation of activin βA and βB expression by gonadotropin in the zebrafish ovarian follicle cells. Endocrinology, 144: 491-499 (IF=5.045)
63. Wang Y#, Wong AOL & Ge W (2003) Cloning, regulation of mRNA expression and function of a new isoform of pituitary adenylate cyclase-activating polypeptide (PACAP) in the zebrafish ovary. Endocrinology, 144: 4799-4810 (IF=5.045)
64. Wang Y# & Ge W (2003) Spatial expression patterns of activin and its signaling system in the zebrafish ovarian follicle: Evidence for paracrine action of activin on the oocytes. Biology of Reproduction, 69: 1998-2006 (IF=3.670)
65. Wang Y# & Ge W (2003) Gonadotropin regulation of follistatin expression in the cultured ovarian follicle cells of zebrafish, Danio rerio. General and Comparative Endocrinology, 134: 308-315 (IF=3.108)
66. Wang Y# & Ge W (2002) Cloning of zebrafish ovarian carbonyl reductase-like 20β-hydroxysteroid dehydrogenase and characterization of its spatial and temporal expression. General and Comparative Endocrinology, 127: 209-216 (IF=3.108).
科研用书章节撰写(Book Chapter)
1. Wang Yajun*. Book Chapter 29: <Overviews of avian neuropeptides and peptides>, 2022, Book Title: <Sturkie's Avian Physiology >, Edited by Scanes, C. G., & Dridi, S. (Eds.). Academic Press，pp. 717-757
2. Wang Yajun*. Book Chapter 12: <Novel Peptides in Poultry：A case study of the expanding glucagons peptide superfamily in chickens (Gallus gallus)>, 2017, Book Title: <Biology of Domestic Animals>, Edited by Scanes CG & Hill R. Science Publisher，pp.343-352
国际会议报告
1. 王亚军 The 11th International Symposium on Avian Endocrinology 2016 (ISAE2016) (Canada, 2016) (大会报告, 25 min. Invited Speaker).
Title: Molecular Characterization of the Key Regulators in Avian Energy Balance: A Tale in Birds.
2. 王亚军 Physiology2014 (London UK, The Physiological Society, 2014) (Invited Speaker) Title: Extra-pituitary Prolactin and Prolactin-like Hormone in Zebrafish and Chickens.
3. 王亚军 The 10th International Symposium on Avian Endocrinology 2012 (ISAE2012) (Japan, 2012). (大会报告, 25 min. Invited Speaker).
Title: Molecular Characterization of the Receptors for Chicken GHRH, PrRP, and Their Related Peptides: An Emerging Evolutionary Story.
本课题组招收硕士/博士/博士后，欢迎感兴趣的同学联系。
